tag:blogger.com,1999:blog-17889588.post7298535426347543593..comments2024-03-13T07:14:55.283+01:00Comments on chem-bla-ics: What is dapagliflozin?Egon Willighagenhttp://www.blogger.com/profile/07470952136305035540noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-17889588.post-6799658400903792832007-09-01T04:11:00.000+02:002007-09-01T04:11:00.000+02:00Egon...the structure that you posted to Wikipedia ...Egon...the structure that you posted to Wikipedia has lost the stereochemistry from the ring (see the question marks in the stereo layer). I'd suggest correcting it for accuracy.<BR/><BR/>Also, the structure deposition functionality we've been promising on ChemSpider is now in beta..if you'd like to take a look let me know. The link below was generated with about 3 minutes work once I'd drawn the structure (actually converted your Wikipedia InChI and added stereo back in).<BR/><BR/>http://www.chemspider.com/docs/dapagliflozin.png<BR/><BR/>This capability will be generically available to everyone shortly and is one step further along to the wiki-like environment we've been promising...and yes, we have lots more to do.ChemSpidermanhttps://www.blogger.com/profile/12619309311131629965noreply@blogger.comtag:blogger.com,1999:blog-17889588.post-82389277035618832402007-08-21T02:24:00.000+02:002007-08-21T02:24:00.000+02:00Here is where the structure of dapagliflozin is po...Here is where the structure of dapagliflozin is posted:<BR/>http://www.ama-assn.org/ama1/pub/upload/mm/365/dapagliflozin.pdfAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-17889588.post-91087709254648978122007-06-26T14:56:00.000+02:002007-06-26T14:56:00.000+02:00Dear Egon,maybe I'm a little bit late with my comm...Dear Egon,<BR/><BR/>maybe I'm a little bit late with my comment, but dapagliflozin is not a DPP-4 inhibitor but a sodium glucose cotransporter type 2 (SGLT-2) inhibitor. Still no concrete structure on the horizon, so no inchi.<BR/>But it should be one of those (see link) , especially the process patent of 2004<BR/>http://www.wipo.int/patentscopedb/en/rss.jsp?C=1&QUERY=%28ABE%2fSGLT%2a%29+AND+%28PA%2fBristol%2a%29+AND+DE%2fglucose+<BR/>So it's a C-aryl glucoside.Anonymousnoreply@blogger.com