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Sunday, March 06, 2022

Contributions to two new papers: skin lipids and AOPs

Figure 2 of the AOP paper showing the
content of the AOP-DB.
Because people are counting, it is hard to decline an invitation to contribute to a paper. Honestly, I rather be invited to contribute to research, but as I am told in a far past: writing papers and grant proposals make you think better about your research. Mmm, yes, that's because without those I never thought about my research. Anyways, These cross-project collaborations are really nice, and thank the leading authors for our joined efforts. I always then think that we can achieve that with a properly crafted pull request too and only if those were recognized and rewarded too. So, here I post some recent papers to which I or people paid by my research money (yeah, another thing we should discuss) have contributed too.

Skin lipids

The first such papers is a review of the state of studying lipids in our skin: Research Techniques Made Simple: Lipidomic Analysis in Skin Research (doi:10.1016/j.jid.2021.09.017). This paper originates from WG4 of the EpiLipidNet project (funded by COST) where we are developing molecular pathways involving lipids. Florian Gruber is chair of WG4 and our role is the pathways. We have set up lipids.wikipathways.org for this and the article further mentions the pathway and network system biology approaches used in our group.

Adverse Outcome Pathways

Combining Adverse Outcome Pathways (AOPs) with molecular pathways is one of the longer running research lines in our group. This already started during the eNanoMapper project and Marvin has been studying alternative approaches in his PhD projected funded by OpenRiskNet and EU-ToxRisk. During OpenRiskNet he collaborated with the team of Holly Mortensen of the USA EPA resulting in some collaborative projects. One outcome is the recent EPA paper on an RDF version of their AOP-DB: The AOP-DB RDF: Applying FAIR Principles to the Semantic Integration of AOP Data Using the Research Description Framework (doi:10.3389/ftox.2022.803983).

Thanks again to everyone involved in these papers for these nice collaborations!

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