Figure 2 of the AOP paper showing the content of the AOP-DB. |
Skin lipids
The first such papers is a review of the state of studying lipids in our skin: Research Techniques Made Simple: Lipidomic Analysis in Skin Research (doi:10.1016/j.jid.2021.09.017). This paper originates from WG4 of the EpiLipidNet project (funded by COST) where we are developing molecular pathways involving lipids. Florian Gruber is chair of WG4 and our role is the pathways. We have set up lipids.wikipathways.org for this and the article further mentions the pathway and network system biology approaches used in our group.
Adverse Outcome Pathways
Combining Adverse Outcome Pathways (AOPs) with molecular pathways is one of the longer running research lines in our group. This already started during the eNanoMapper project and Marvin has been studying alternative approaches in his PhD projected funded by OpenRiskNet and EU-ToxRisk. During OpenRiskNet he collaborated with the team of Holly Mortensen of the USA EPA resulting in some collaborative projects. One outcome is the recent EPA paper on an RDF version of their AOP-DB: The AOP-DB RDF: Applying FAIR Principles to the Semantic Integration of AOP Data Using the Research Description Framework (doi:10.3389/ftox.2022.803983).
Thanks again to everyone involved in these papers for these nice collaborations!
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